Abstract Search

ea0007p92 | Endocrine tumours and neoplasia | BES2004

Inhibition of cell proliferation, but lack of antiangiogenic effect on GH-secreting pituitary adenomas treated with Lanreotide

Garcia|#Torre N , Sullivan N , Fazal-Sanderson V , Nagy Z , Wass J , Ansorge O , Turner H

Background: Current available data demonstrate the ability of somatostatin analogues (Ssan) to reduce tumoral size in GH-secreting pituitary adenomas. Somatostatin receptors are present on both tumour cells and vascular endothelium; therefore, potential mechanisms for tumour shrinkage with Ssan include inhibition of cell proliferation, increased cell loss, and inhibition of angiogenesis.Objective: To assess the mechanisms for tumour shrinkage in GH-secre...

0 shares

ea0013p244 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Non-surgical cerebro-spinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiological and clinicopathological features

Suliman SGI , Gurlek A , Byrne J , Sullivan N , Thanabalasingham G , Cudlip S , Ansorge O , Wass JAH

Objective: Macroprolactinomas (MPRL) may result in spontaneous or dopamine-agonist-induced CSF rhinorrhoea. The incidence of, and mechanisms underlying this phenomenon are poorly understood. In this study, we aimed to determine the incidence of non-surgical (spontaneous and dopamine-agonist-induced) rhinorrhoea, and to identify biochemical, radiological and histopathological factors associated with this phenomenon.Methods: We retrospectively reviewed MPR...

0 shares

Endocrine Abstracts

Inhibition of cell proliferation, but lack of antiangiogenic effect on GH-secreting pituitary adenomas treated with Lanreotide

Non-surgical cerebro-spinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiological and clinicopathological features

BiosciAbstracts